Vineatrol

Health Properties: Vineatrol may be useful in Heart Disease, Alzheimer's, Cancer, Leukemia and Epilepsy. It may also promote longevity in general. Vineatrol has similar properties to resveratrol but the former is stronger. While vineatrol is obtained from the young vine shoots and leaves, resveratrol is found in the skins of the grape and in red wine (as well as eucalyptus, spruce, blueberries, mulberries, peanuts and giant knotweed).

The greater effectiveness of vineatrol is due to its trans-resveratrol molecular form. There is a greater abundance of the "trans" form compared to the other forms of resveratrol in vineatrol.

Pathways of Vineatrol:

• anti-oxidant; resveratrol inhibits lipid peroxidation of low-density lipoprotein and prevents the cytotoxicity of oxidized LDL;
• anti-inflammatory;
• anti-platelet activity;
• dilates the vascular system through eNOS stimulation;
• anti-Amyloidbeta effects; resveratrol promotes Amyloidbeta peptide degradation via a mechanism that involves the proteasome;
• lowers LDL ("bad cholesterol");
• anti-proliferation of some cancer cells;
• induces apoptosis (suicide) in some cancer cells; vineatrol will interrupt cancer in some cell lines at all three stages (initiation, replication and metastasis);
• Affects COX-1, lipoxygenase, transcription factor NF-kB, cytochrome P450, isoenzyme CYP1A1.

Scientific Data of Vineatrol

• Molecular weight: 228;
• Formula: C14H12O3;
• Other Names: Trans-3,5,4'-trihydroxystilbene; 3,4',5-stilbenetriol;
• Forms: Trans-resveratrol, Cis-resveratrol, Viniferin (dimer);
• Other Interesting Forms: the methoxy- form is mentioned in relation to potent and selective apoptosis of cancer cell lines and to the potentiation of its anti-amyloid activity;
• Metabolites: -glucuronate; -sulfonate

• Yeast: 70%;
  
• Northobranchius furzeri (type of fish): 59%;
  
• Humans: ?
  

Natural Sources of Vineatrol

• the vine which consistently produces the most resveratrol is Pinot Noir, no matter what the region. This fact puts most Pinot Noir regions of the world on a par.
• it is the cool climate areas where non-Pinot-Noir grapes produce the most resveratrol: Bourdeaux, Ontario in Canada, and the Yarra Valley in Australia. New areas are queing up to get on this list including rural New York, the south island of New Zealand and Tasmania. Latitude 44 degrees, north or south, may be the general indicator, but local climates and niches will hold sway.
• the wine-making practice which is essential is maceration of the skins and seeds in the fermentation.

Obtaining the benefit of resveratrol in the wine, grape or juice form would require a French diet beginning from age 12 years and lasting for a persons lifetime for the diet to be effective. Taking the capsule as a concentrate puts the substance into a more effective form for the treatment of disease. For vineatrol, taking the young leaves directly from the vine is an interesting idea but is limited to the growing season and one must be cognizant of the therapeutic dosage.

Vineatrol is also more plentiful in the vineshoots and young vine leaves, being measured in milligrams rather than the micrograms found in the grapeskins and the wine itself. Comparing the availability in vine-shoots versus mature leaves, it is in the former that one finds the molecule in relative abundance. The current interest in resveratrol (Google count = 960,000) is likely to transfer to vineatrol once it becomes more widely known that vineatrol has the molecule in the correct form and in great abundance. This should come as some relief for the vigneron who may now leave the grape skin in the fermentation vat to make wine, yet allowing him to profit from the new industry by obtaining the substance from spring prunings of the young vine-shoots, thus allowing a clearly separate industry to emerge on the farm.

Vineatrol: Quotations from Recent Studies